How to Watch: Mayer-Ryan 2 will be broadcast Saturday LIVE on ESPN, ESPN Deportes, and ESPN+ at 2am GMT / 10pm ET / 7pm PT. The ESPN+-streamed undercard begins at 11pm GMT / 7pm ET / 4pm PT.
Six months after their first fight, which Mayer won via majority decision, the bitter rivals will lock horns again and the flames of their rivalry just keep on rising higher.
They animosity initially stemmed from the American two-weight world champion after the Brit joined her gym and apparently "stole" her trainer away from her.
Then, when the pair met in September 2024 to settle their feud, Sandy Ryan was attacked on her way to the venue when someone ran up to her in the street and threw a can of red paint all over her, then quickly jumped into a passing car, which was a clearly well-timed attacked.

Mayer condemned the action, but Ryan accused her of being behind, posing the question, 'Who else knew when we were leaving the hotel?'.
WBO welterweight world champion Mikaela Mayer and Sandy Ryan faced off in advance of Saturday's rematch at Bleaulive Theater at Fontainebleau Las Vegas. The war of words evolved into a long, steely staredown Wednesday afternoon outside of the Bleaulive Theater.

In the co-feature, Brian Norman Jr. (26-0, 20 KOs) will make the inaugural defence of his WBO welterweight world championship against Puerto Rican challenger Derrieck Cuevas (27-1-1, 19 KOs).
The ESPN+-streamed undercard features Brooklyn featherweight phenom Bruce “Shu Shu” Carrington (14-0, 8 KOs), who faces Mexican slugger Jose Enrique Vivas (23-3, 12 KOs) in a 10-round WBC final eliminator.
Promoted by Top Rank, in association with MatchroomBoxing, tickets are available via Ticketmaster.com.
This is what Mayer and Ryan had to say to Sky Sports after Wednesday's faceoff:
"You can see she loves the attention, the talk. When you don't give her that, it triggers her. So, she's saying, 'Oh, she's scared.' I'm not scared. We just did a faceoff. This is for the media. This is what's in the contract, and we're here. She loves to talk and loves the media. When you don't give her that, it makes her talk all kinds of nonsense."
"She thinks she's so tricky. We know that's how she is. We know she's going to say that because she doesn't like to engage anyway, and neither does her coach. Her coach wants to hide and stay in the shadows, and he's probably telling her, 'Don't engage.' I'm just doing what I have to do. I don't do anything but speak the facts, and I'm doing my part to sell this fight. Everyone is coming together and working hard to give her the rematch that she wanted. The least she can do is show up and help the promotion of this fight."
ESPN, ESPN Deportes and ESPN+ (2am GMT / 10pm ET / 7pm PT)
Mikaela Mayer vs. Sandy Ryan
10x2 Mayer's WBO Welterweight World Title
Brian Norman Jr. vs. Derrieck Cuevas
12x3 Norman's WBO Welterweight World Title
ESPN+ (11pm GMT / 7pm ET / 4pm PT)
Bruce Carrington vs. Jose Enrique Vivas
10x3 WBC featherweight eliminator
Emiliano Fernando Vargas vs. Giovannie Gonzalez
8x3 junior welterweight
Tiger Johnson vs. Kendo Castañeda
8x3 welterweight
Dedrick Crocklem vs. Dionne Ruvalcaba
4x3 junior lightweight
Emmanuel Chance vs. Miguel Guzman
4x3 bantamweight